Version 5.4
Mus musculus Protein: Arhgap31
Summary
InnateDB Protein IDBP-160605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap31
Protein Name Rho GTPase activating protein 31
Synonyms 5830477L08Rik; AU041750; Cdgap; D330026I07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000023487
InnateDB Gene IDBG-160603 (Arhgap31)
Protein Structure
UniProt Annotation
Function Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269PubMed:16860736, ECO:0000269PubMed:9786927}.
Subcellular Localization Cell projection, lamellipodium. Cell junction, focal adhesion.
Disease Associations
Tissue Specificity Expressed at highest levels in heart and lung. {ECO:0000269PubMed:9786927}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005925 focal adhesion
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID MGI:1333857
InterPro IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PRINTS
PIRSF
SMART SM00324
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6X8Z5
PhosphoSite PhosphoSite-NP_064656
TrEMBL B2RSI0
UniProt Splice Variant
Entrez Gene 12549
UniGene Mm.474958
RefSeq NP_064656
MGI ID
MGI Symbol Arhgap31
OMIM
CCDS CCDS28172
HPRD
IMGT
EMBL AC154425 AF151363 AK129309 AK138417 AK149975 AK150109 AK155729 AK166583 AK166622 BC138870 CH466521 CT009576
GenPept AAD38043 AAI38871 BAC98119 BAE23651 BAE29205 BAE29314 BAE33406 BAE38872 BAE38901 CAO77869 EDK97988

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca