InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcgf5

Summary

InnateDB Protein

IDBP-160611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcgf5

Protein Name

polycomb group ring finger 5

Synonyms

0610009F02Rik; 1110054A01Rik; 5830406C17Rik; 5830443C21Rik; 9530023M17Rik; AI324127;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058730

InnateDB Gene

IDBG-160609 (Pcgf5)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005813	centrosome
GO:0031519	PcG protein complex

Protein Structure and Domains

PDB ID

MGI:1923505

InterPro

IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00097

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UK78

PhosphoSite

PhosphoSite-Q3UK78

TrEMBL

UniProt Splice Variant

Entrez Gene

76073

UniGene

RefSeq

XP_006527494

MGI ID

MGI Symbol

Pcgf5

OMIM

CCDS

CCDS29772

HPRD

IMGT

EMBL

AK002387 AK017984 AK146133 BC139258 BC139259 BC145590

GenPept

AAI39259 AAI39260 AAI45591 BAB22061 BAB31023 BAE26924