InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcsk7

Summary

InnateDB Protein

IDBP-160621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcsk7

Protein Name

proprotein convertase subtilisin/kexin type 7

Synonyms

AA959856; PC7; SPC7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047508

InnateDB Gene

IDBG-160619 (Pcsk7)

Protein Structure

UniProt Annotation

Function

Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in brain, lung, muscle, heart, liver, kidney, spleen and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0030173	integral component of Golgi membrane

Protein Structure and Domains

PDB ID

MGI:107421

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61139