InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ankrd54

Summary

InnateDB Protein

IDBP-160671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ankrd54

Protein Name

ankyrin repeat domain 54

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047042

InnateDB Gene

IDBG-160669 (Ankrd54)

Protein Structure

UniProt Annotation

Function

Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. {ECO:0000269PubMed:19064729}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19064729}. Cytoplasm {ECO:0000269PubMed:19064729}. Midbody {ECO:0000269PubMed:19064729}. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation.

Disease Associations

Tissue Specificity

Expressed in a variety of hemopoietic cell lines and tissue with high levels in testis. Highly expressed in ciliated cells. {ECO:0000269PubMed:17971504, ECO:0000269PubMed:19064729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019887	protein kinase regulator activity
GO:0032403	protein complex binding

Biological Process

GO:0006913	nucleocytoplasmic transport
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045859	regulation of protein kinase activity
GO:1902531	regulation of intracellular signal transduction