InnateDB Protein
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IDBP-160708.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Las1l
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Protein Name
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LAS1-like (S. cerevisiae)
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Synonyms
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1810030A06Rik; 5830482G23Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000078901
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InnateDB Gene
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IDBG-160706 (Las1l)
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Protein Structure
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Function |
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000250, ECO:0000269PubMed:22872859}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000269PubMed:22872859}. Cytoplasm {ECO:0000269PubMed:22872859}. Note=Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923380
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InterPro |
IPR007174
Las1-like
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PFAM |
PF04031
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A2BE28
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PhosphoSite |
PhosphoSite-A2BE28
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
76130
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UniGene |
Mm.274318
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RefSeq |
NP_690035
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MGI ID |
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MGI Symbol |
Las1l
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OMIM |
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CCDS |
CCDS30287
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HPRD |
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IMGT |
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EMBL |
AK052578
AK131142
BC141155
BX005184
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GenPept |
AAI41156
BAC35047
BAD21392
CAM25407
CAM25408
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