InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pmf1

Summary

InnateDB Protein

IDBP-160716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pmf1

Protein Name

polyamine-modulated factor 1

Synonyms

2600009M07Rik; AL033286; AW060657;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062420

InnateDB Gene

IDBG-160712 (Pmf1)

Protein Structure

UniProt Annotation

Function

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity). May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. {ECO:0000250, ECO:0000269PubMed:11583586}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Associated with the kinetochore. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043522	leucine zipper domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division