InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Micall1

Summary

InnateDB Protein

IDBP-160802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Micall1

Protein Name

microtubule associated monoxygenase, calponin and LIM domain containing -like 1

Synonyms

260; AI448246; D15Mit260; D15N2e; EST573322; EST820961; MIRab13; mKIAA1668;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042053

InnateDB Gene

IDBG-160800 (Micall1)

Protein Structure

UniProt Annotation

Function

Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. {ECO:0000269PubMed:23572513}.

Subcellular Localization

Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}. Note=Localization to late endosomes is actin- dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding
GO:0042802	identical protein binding
GO:0070300	phosphatidic acid binding

Biological Process

GO:0006612	protein targeting to membrane
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0031175	neuron projection development
GO:0032458	slow endocytic recycling
GO:0036010	protein localization to endosome
GO:0097320	membrane tubulation
GO:1990090	cellular response to nerve growth factor stimulus
GO:1990126	retrograde transport, endosome to plasma membrane

Cellular Component

GO:0005770	late endosome
GO:0010008	endosome membrane
GO:0019898	extrinsic component of membrane
GO:0031902	late endosome membrane
GO:0055038	recycling endosome membrane

Protein Structure and Domains

PDB ID

MGI:105870

InterPro

IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022735 Domain of unknown function DUF3585

PFAM

PF00307
PF00412
PF11971
PF12130

PRINTS

PIRSF

SMART

SM00033
SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BGT6