InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Igsf11

Summary

InnateDB Protein

IDBP-160814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igsf11

Protein Name

immunoglobulin superfamily, member 11

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023478

InnateDB Gene

IDBG-160812 (Igsf11)

Protein Structure

UniProt Annotation

Function

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in testis and detected in kidney and adrenal gland. In brain, expressed in commissure fibers of the corpus callosum and pyramidal cell layers of the dentate gyrus and hippocampus where it is probably expressed by both neurons and glial cells. {ECO:0000269PubMed:12207903}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0040008	regulation of growth

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2388477

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain

PFAM

PF07679
PF07686

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P0C673