InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMM13

Summary

InnateDB Protein

IDBP-16083.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMM13

Protein Name

translocase of inner mitochondrial membrane 13 homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215570

InnateDB Gene

IDBG-16081 (TIMM13)

Protein Structure

UniProt Annotation

Function

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269PubMed:11489896, ECO:0000269PubMed:15254020}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:11489896}; Peripheral membrane protein {ECO:0000269PubMed:11489896}; Intermembrane side {ECO:0000269PubMed:11489896}.

Disease Associations

Tissue Specificity

Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0007605	sensory perception of sound
GO:0044267	cellular protein metabolic process
GO:0072321	chaperone-mediated protein transport

Cellular Component

GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0042719	mitochondrial intermembrane space protein transporter complex