InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npm1

Summary

InnateDB Protein

IDBP-160842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npm1

Protein Name

nucleophosmin 1

Synonyms

B23; NO38; Npm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075067

InnateDB Gene

IDBG-160840 (Npm1)

Protein Structure

UniProt Annotation

Function

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Colocalizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. NEK2 is required for its localization to the centrosome during mitosis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in B-cells that have been induced to switch to various Ig isotypes. {ECO:0000269PubMed:9642267}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 172 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	172 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0019843	rRNA binding
GO:0019899	enzyme binding
GO:0043023	ribosomal large subunit binding
GO:0043024	ribosomal small subunit binding
GO:0051059	NF-kappaB binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000055	ribosomal large subunit export from nucleus
GO:0000056	ribosomal small subunit export from nucleus
GO:0006281	DNA repair
GO:0006407	rRNA export from nucleus
GO:0006884	cell volume homeostasis
GO:0006913	nucleocytoplasmic transport
GO:0007098	centrosome cycle
GO:0007569	cell aging
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010824	regulation of centrosome duplication
GO:0010825	positive regulation of centrosome duplication
GO:0016049	cell growth
GO:0031328	positive regulation of cellular biosynthetic process
GO:0032071	regulation of endodeoxyribonuclease activity
GO:0042273	ribosomal large subunit biogenesis
GO:0042274	ribosomal small subunit biogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043523	regulation of neuron apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045727	positive regulation of translation
GO:0045740	positive regulation of DNA replication
GO:0045860	positive regulation of protein kinase activity
GO:0046599	regulation of centriole replication
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0051054	positive regulation of DNA metabolic process
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0051726	regulation of cell cycle
GO:0060699	regulation of endoribonuclease activity
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA

Cellular Component

GO:0001652	granular component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0015934	large ribosomal subunit
GO:0015935	small ribosomal subunit
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex