Version 5.4
Mus musculus Protein: Npm1
Summary
InnateDB Protein IDBP-160844.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Npm1
Protein Name nucleophosmin 1
Synonyms B23; NO38; Npm;
Species Mus musculus
Ensembl Protein ENSMUSP00000090891
InnateDB Gene IDBG-160840 (Npm1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 172 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 172 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006407 rRNA export from nucleus
GO:0006884 cell volume homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0008104 protein localization
GO:0008284 positive regulation of cell proliferation
GO:0010824 regulation of centrosome duplication
GO:0010825 positive regulation of centrosome duplication
GO:0016049 cell growth
GO:0031328 positive regulation of cellular biosynthetic process
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045860 positive regulation of protein kinase activity
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0051259 protein oligomerization
GO:0051726 regulation of cell cycle
Cellular Component
GO:0001652 granular component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0015934 large ribosomal subunit
GO:0015935 small ribosomal subunit
GO:0016607 nuclear speck
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:106184
InterPro IPR024057 Nucleoplasmin core domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5SQB0
UniProt Splice Variant
Entrez Gene 18148
UniGene Mm.485384
RefSeq
MGI ID
MGI Symbol Npm1
OMIM
CCDS
HPRD
IMGT
EMBL AL772409
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca