Version 5.4
Mus musculus Protein: Mob1a
Summary
InnateDB Protein IDBP-160854.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mob1a
Protein Name MOB kinase activator 1A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039115
InnateDB Gene IDBG-160850 (Mob1a)
Protein Structure
UniProt Annotation
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0035329 hippo signaling
Cellular Component
Protein Structure and Domains
PDB ID MGI:2442631
InterPro IPR005301 Mob1/phocein
PFAM PF03637
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q921Y0
PhosphoSite PhosphoSite-Q921Y0
TrEMBL
UniProt Splice Variant
Entrez Gene 232157
UniGene Mm.487282
RefSeq
MGI ID
MGI Symbol Mob1a
OMIM
CCDS
HPRD
IMGT
EMBL AK028416 AK028695 AK167515 AK172205 BC009149 BC033463
GenPept AAH09149 AAH33463 BAC25938 BAC26070 BAE39589 BAE42880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca