Version 5.4
Mus musculus Protein: Abhd4
Summary
InnateDB Protein IDBP-160872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abhd4
Protein Name abhydrolase domain containing 4
Synonyms 1110035H23Rik; Abh4; AI429574;
Species Mus musculus
Ensembl Protein ENSMUSP00000044134
InnateDB Gene IDBG-160868 (Abhd4)
Protein Structure
UniProt Annotation
Function Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. {ECO:0000269PubMed:16818490}.
Subcellular Localization
Disease Associations
Tissue Specificity Highest levels in the CNS and in testis, intermediate levels in liver and kidney. Hardly detectable in heart. {ECO:0000269PubMed:16818490}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0016042 lipid catabolic process
Cellular Component
Protein Structure and Domains
PDB ID MGI:1915938
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PRINTS PR00111
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VD66
PhosphoSite PhosphoSite-Q8VD66
TrEMBL Q8C0M2
UniProt Splice Variant
Entrez Gene 105501
UniGene Mm.28771
RefSeq NP_598837
MGI ID
MGI Symbol Abhd4
OMIM
CCDS CCDS56954
HPRD
IMGT
EMBL AK030250 AK049366 AK152595 AK161853 BC017532 CT573018
GenPept AAH17532 BAC26863 BAC33711 BAE31344 BAE36606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca