InnateDB Protein
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IDBP-160914.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp1r3c
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Protein Name
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protein phosphatase 1, regulatory (inhibitor) subunit 3C
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Synonyms
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Ppp1r5; PTG;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000084578
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InnateDB Gene
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IDBG-160912 (Ppp1r3c)
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Protein Structure
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Function |
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000269PubMed:10683377, ECO:0000269PubMed:10862764, ECO:0000269PubMed:10998419, ECO:0000269PubMed:12727934, ECO:0000269PubMed:12805359, ECO:0000269PubMed:15322104, ECO:0000269PubMed:16354703, ECO:0000269PubMed:9045612, ECO:0000269PubMed:9242697, ECO:0000269PubMed:9756875}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1858229
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InterPro |
IPR005036
Putative phosphatase regulatory subunit
IPR017434
Protein phosphatase 1, glycogen targeting subunit, Metazoa
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PFAM |
PF03370
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PRINTS |
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PIRSF |
PIRSF038207
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TMB3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
53412
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UniGene |
Mm.24724
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RefSeq |
NP_058550
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MGI ID |
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MGI Symbol |
Ppp1r3c
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OMIM |
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CCDS |
CCDS37968
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HPRD |
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IMGT |
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EMBL |
AK078506
BC052769
BC054739
U89924
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GenPept |
AAB49689
AAH52769
AAH54739
BAC37313
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