InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnks2

Summary

InnateDB Protein

IDBP-160920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnks2

Protein Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Synonyms

5430432P15Rik; AA517131; AI662480; ARTD6; Tank2; TNKS-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025729

InnateDB Gene

IDBG-160918 (Tnks2)

Protein Structure

UniProt Annotation

Function

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0000723	telomere maintenance
GO:0006471	protein ADP-ribosylation
GO:0016055	Wnt signaling pathway
GO:0035264	multicellular organism growth
GO:0040014	regulation of multicellular organism growth
GO:0070198	protein localization to chromosome, telomeric region
GO:0070213	protein auto-ADP-ribosylation
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0000242	pericentriolar material
GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1921743

InterPro

IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM