InnateDB Protein
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IDBP-160929.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Polr2f
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Protein Name
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polymerase (RNA) II (DNA directed) polypeptide F
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Synonyms
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1810060D16Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000043566
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InnateDB Gene
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IDBG-160927 (Polr2f)
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Protein Structure
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Function |
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006360
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transcription from RNA polymerase I promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006383
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transcription from RNA polymerase III promoter
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Cellular Component |
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PDB ID |
MGI:1349393
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InterPro |
IPR006110
RNA polymerase, subunit omega/K/RPB6
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PFAM |
PF01192
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61219
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PhosphoSite |
PhosphoSite-P61219
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
69833
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UniGene |
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RefSeq |
NP_081507
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MGI ID |
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MGI Symbol |
Polr2f
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OMIM |
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CCDS |
CCDS27634
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HPRD |
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IMGT |
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EMBL |
AK007913
BC024419
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GenPept |
AAH24419
BAB25345
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