InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gap43

Summary

InnateDB Protein

IDBP-160943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gap43

Protein Name

growth associated protein 43

Synonyms

B-50; Basp2; GAP-43;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099881

InnateDB Gene

IDBG-160941 (Gap43)

Protein Structure

UniProt Annotation

Function

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0010001	glial cell differentiation
GO:0016198	axon choice point recognition
GO:0040008	regulation of growth
GO:0042246	tissue regeneration
GO:0045165	cell fate commitment
GO:0051489	regulation of filopodium assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0031527	filopodium membrane
GO:0032584	growth cone membrane
GO:0045202	synapse
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:95639

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001422 Neuromodulin (GAP-43)
IPR017454 Neuromodulin (GAP-43), C-terminal
IPR018947 Neuromodulin gap junction N-terminal

PFAM

PF00612
PF06614
PF10580

PRINTS

PR00215

PIRSF

SMART

SM00015

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt