Version 5.4
Mus musculus Protein: Cc2d2a
Summary
InnateDB Protein IDBP-160974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cc2d2a
Protein Name coiled-coil and C2 domain containing 2A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000048320
InnateDB Gene IDBG-160972 (Cc2d2a)
Protein Structure
UniProt Annotation
Function Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. {ECO:0000269PubMed:21725307, ECO:0000269PubMed:22179047}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21725307}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:21725307}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007224 smoothened signaling pathway
GO:0042384 cilium assembly
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0035869 ciliary transition zone
GO:0036038 TCTN-B9D complex
Protein Structure and Domains
PDB ID MGI:1924487
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFW7
PhosphoSite PhosphoSite-Q8CFW7
TrEMBL D3YZ31
UniProt Splice Variant
Entrez Gene 231214
UniGene Mm.486802
RefSeq NP_758478
MGI ID
MGI Symbol Cc2d2a
OMIM
CCDS CCDS39080
HPRD
IMGT
EMBL AC140277 AC161536 AK077658 BC032290
GenPept AAH32290 BAC36933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca