InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox10

Summary

InnateDB Protein

IDBP-160983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox10

Protein Name

SRY-box containing gene 10

Synonyms

Dom; Sox21;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039466

InnateDB Gene

IDBG-160981 (Sox10)

Protein Structure

UniProt Annotation

Function

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042802	identical protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001755	neural crest cell migration
GO:0002052	positive regulation of neuroblast proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007422	peripheral nervous system development
GO:0014015	positive regulation of gliogenesis
GO:0030154	cell differentiation
GO:0030318	melanocyte differentiation
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048484	enteric nervous system development
GO:0048546	digestive tract morphogenesis
GO:0048589	developmental growth
GO:0048709	oligodendrocyte differentiation
GO:0048863	stem cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway