InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptch1

Summary

InnateDB Protein

IDBP-161039.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptch1

Protein Name

patched homolog 1

Synonyms

A230106A15Rik; mes; Ptc; Ptc1; Ptch;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021921

InnateDB Gene

IDBG-161037 (Ptch1)

Protein Structure

UniProt Annotation

Function

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. {ECO:0000269PubMed:21537345}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005113	patched binding
GO:0005119	smoothened binding
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0008201	heparin binding
GO:0008270	zinc ion binding
GO:0015485	cholesterol binding
GO:0030332	cyclin binding
GO:0032403	protein complex binding
GO:0097108	hedgehog family protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001701	in utero embryonic development
GO:0001841	neural tube formation
GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007346	regulation of mitotic cell cycle
GO:0007389	pattern specification process
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008544	epidermis development
GO:0008589	regulation of smoothened signaling pathway
GO:0009612	response to mechanical stimulus
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0010157	response to chlorate
GO:0010875	positive regulation of cholesterol efflux
GO:0014070	response to organic cyclic compound
GO:0016485	protein processing
GO:0021522	spinal cord motor neuron differentiation
GO:0021532	neural tube patterning
GO:0021904	dorsal/ventral neural tube patterning
GO:0021997	neural plate axis specification
GO:0030326	embryonic limb morphogenesis
GO:0030879	mammary gland development
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032880	regulation of protein localization
GO:0035108	limb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0040008	regulation of growth
GO:0040015	negative regulation of multicellular organism growth
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616	keratinocyte proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045668	negative regulation of osteoblast differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048568	embryonic organ development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051782	negative regulation of cell division
GO:0060037	pharyngeal system development
GO:0060603	mammary gland duct morphogenesis
GO:0060644	mammary gland epithelial cell differentiation
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005	cell differentiation involved in kidney development
GO:0061053	somite development
GO:0071397	cellular response to cholesterol
GO:0072001	renal system development
GO:0072203	cell proliferation involved in metanephros development
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030496	midbody
GO:0043231	intracellular membrane-bounded organelle
GO:0044294	dendritic growth cone
GO:0044295	axonal growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0072372	primary cilium