InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Blvrb

Summary

InnateDB Protein

IDBP-161059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Blvrb

Protein Name

biliverdin reductase B (flavin reductase (NADPH))

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043092

InnateDB Gene

IDBG-161057 (Blvrb)

Protein Structure

UniProt Annotation

Function

Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004074	biliverdin reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042602	riboflavin reductase (NADPH) activity
GO:0050662	coenzyme binding