InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUF1

Summary

InnateDB Protein

IDBP-16110.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUF1

Protein Name

GUF1 GTPase homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000281543

InnateDB Gene

IDBG-16106 (GUF1)

Protein Structure

UniProt Annotation

Function

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. {ECO:0000255HAMAP-Rule:MF_03137}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000255HAMAP-Rule:MF_03137}; Peripheral membrane protein {ECO:0000255HAMAP-Rule:MF_03137}; Matrix side {ECO:0000255HAMAP- Rule:MF_03137}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0043022	ribosome binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0007264	small GTPase mediated signal transduction
GO:0045727	positive regulation of translation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR006297 Elongation factor 4
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR013842 GTP-binding protein LepA, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF00071
PF03144
PF14492
PF06421

PRINTS

PR00315
PR00449

PIRSF

SMART

SM00838

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt