Version 5.4
Mus musculus Protein: Gabrp
Summary
InnateDB Protein IDBP-161167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gabrp
Protein Name gamma-aminobutyric acid (GABA) A receptor, pi
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020366
InnateDB Gene IDBG-161165 (Gabrp)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2387597
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008100 Gamma-aminobutyric-acid A receptor pi subunit
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01724
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8QZW7
PhosphoSite PhosphoSite-
TrEMBL A8Y5I7
UniProt Splice Variant
Entrez Gene 216643
UniGene Mm.99989
RefSeq NP_666129
MGI ID
MGI Symbol Gabrp
OMIM
CCDS CCDS24535
HPRD
IMGT
EMBL AK028946 AK160577 AL669814 BC023693 BC025550 BC027245 BC031196
GenPept AAH23693 AAH25550 AAH27245 AAH31196 BAC26209 BAE35885 CAI25681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca