InnateDB Protein
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IDBP-161180.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Qtrtd1
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Protein Name
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queuine tRNA-ribosyltransferase domain containing 1
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Synonyms
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3110012M05Rik; 4930470H18Rik; AI648807;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023387
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InnateDB Gene
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IDBG-161178 (Qtrtd1)
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Protein Structure
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Function |
Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). {ECO:0000255HAMAP- Rule:MF_03043, ECO:0000269PubMed:19414587}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03043, ECO:0000269PubMed:19414587}. Mitochondrion {ECO:0000255HAMAP- Rule:MF_03043, ECO:0000269PubMed:19414587}. Note=May associate with the mitochondrion outer membrane.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. {ECO:0000269PubMed:19414587}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1922194
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InterPro |
IPR002616
tRNA-guanine(15) transglycosylase-like
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PFAM |
PF01702
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Z4YJE9
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UniProt Splice Variant |
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Entrez Gene |
106248
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UniGene |
Mm.449220
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RefSeq |
NP_083404
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MGI ID |
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MGI Symbol |
Qtrtd1
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OMIM |
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CCDS |
CCDS37344
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HPRD |
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IMGT |
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EMBL |
CT025520
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GenPept |
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