Mus musculus Protein: Kcnip1 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Protein | IDBP-161308.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Kcnip1 | ||||||||||||||||
Protein Name | Kv channel-interacting protein 1 | ||||||||||||||||
Synonyms | KCHIP1; Kchip1.2; | ||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Protein | ENSMUSP00000098919 | ||||||||||||||||
InnateDB Gene | IDBG-161306 (Kcnip1) | ||||||||||||||||
Protein Structure | |||||||||||||||||
UniProt Annotation | |||||||||||||||||
Function | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface (By similarity). {ECO:0000250}. | ||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:14572458}; Peripheral membrane protein {ECO:0000269PubMed:14572458}. | ||||||||||||||||
Disease Associations | |||||||||||||||||
Tissue Specificity | Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei. {ECO:0000269PubMed:15363885}. | ||||||||||||||||
Comments | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||
PDB ID | MGI:1917607 | ||||||||||||||||
InterPro |
IPR002048
EF-hand domain IPR019577 SPARC/Testican, calcium-binding domain |
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PFAM |
PF00036
PF13202 PF13405 PF10591 |
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PRINTS | |||||||||||||||||
PIRSF | |||||||||||||||||
SMART |
SM00054
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TIGRFAMs | |||||||||||||||||
Post-translational Modifications | |||||||||||||||||
Modification | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | Q9JJ57 | ||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 70357 | ||||||||||||||||
UniGene | Mm.252514 | ||||||||||||||||
RefSeq | NP_001277619 | ||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | Kcnip1 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | CCDS70160 | ||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AB075041 AJ278534 AK045948 AK046398 AK081845 AL669814 AL731867 AY050525 AY050526 AY171234 AY647242 BC034241 | ||||||||||||||||
GenPept | AAH34241 AAL12488 AAL12489 AAN77492 AAT68468 BAB78543 BAC32543 BAC32705 BAC38347 CAC82025 CAI25675 CAI25676 CAI25682 CAI26003 CAI26004 | ||||||||||||||||