Version 5.4
Mus musculus Protein: Acer2
Summary
InnateDB Protein IDBP-161379.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acer2
Protein Name alkaline ceramidase 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081473
InnateDB Gene IDBG-161377 (Acer2)
Protein Structure
UniProt Annotation
Function Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1- phosphate. {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0071633 dihydroceramidase activity
Biological Process
GO:0001953 negative regulation of cell-matrix adhesion
GO:0006672 ceramide metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008284 positive regulation of cell proliferation
GO:0010942 positive regulation of cell death
GO:0032526 response to retinoic acid
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035690 cellular response to drug
GO:0046512 sphingosine biosynthetic process
GO:0090285 negative regulation of protein glycosylation in Golgi
Cellular Component
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID MGI:1920932
InterPro IPR008901 Ceramidase
PFAM PF05875
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VD53
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 230379
UniGene Mm.458684
RefSeq NP_001277470
MGI ID
MGI Symbol Acer2
OMIM
CCDS CCDS71417
HPRD
IMGT
EMBL AF282864 AK085306 AY312515 BC059819
GenPept AAH59819 AAL40408 AAQ85131 BAC39416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca