InnateDB Protein
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IDBP-161381.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Acer2
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Protein Name
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alkaline ceramidase 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040048
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InnateDB Gene
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IDBG-161377 (Acer2)
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Protein Structure
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Function |
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1- phosphate. {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016811
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
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GO:0017040
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ceramidase activity
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GO:0071633
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dihydroceramidase activity
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Biological Process |
GO:0001953
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negative regulation of cell-matrix adhesion
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GO:0006672
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ceramide metabolic process
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0008284
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positive regulation of cell proliferation
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GO:0010942
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positive regulation of cell death
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GO:0032526
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response to retinoic acid
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GO:0033629
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negative regulation of cell adhesion mediated by integrin
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GO:0035690
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cellular response to drug
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GO:0046512
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sphingosine biosynthetic process
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GO:0090285
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negative regulation of protein glycosylation in Golgi
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Cellular Component |
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PDB ID |
MGI:1920932
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InterPro |
IPR008901
Ceramidase
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PFAM |
PF05875
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VD53
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
230379
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UniGene |
Mm.458684
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RefSeq |
NP_647467
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MGI ID |
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MGI Symbol |
Acer2
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OMIM |
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CCDS |
CCDS18311
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HPRD |
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IMGT |
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EMBL |
AF282864
AK085306
AY312515
BC059819
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GenPept |
AAH59819
AAL40408
AAQ85131
BAC39416
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