InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stambp

Summary

InnateDB Protein

IDBP-161395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stambp

Protein Name

STAM binding protein

Synonyms

5330424L14Rik; 5730422L11Rik; Amsh; AW107289; mKIAA4198;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070876

InnateDB Gene

IDBG-161393 (Stambp)

Protein Structure

UniProt Annotation

Function

Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain. {ECO:0000269PubMed:11713295}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006508	proteolysis
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016579	protein deubiquitination
GO:0043524	negative regulation of neuron apoptotic process
GO:0046580	negative regulation of Ras protein signal transduction