InnateDB Protein
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IDBP-161407.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Prmt5
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Protein Name
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protein arginine N-methyltransferase 5
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Synonyms
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Jbp1; Skb1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023873
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InnateDB Gene
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IDBG-161405 (Prmt5)
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Protein Structure
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Function |
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter. {ECO:0000269PubMed:15485929, ECO:0000269PubMed:19584108, ECO:0000269PubMed:19858291, ECO:0000269PubMed:21917714, ECO:0000269PubMed:23133559}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:22872859}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
89 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1351645
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InterPro |
IPR007857
Protein arginine N-methyltransferase PRMT5
IPR025799
Protein arginine N-methyltransferase
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF05185
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PRINTS |
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PIRSF |
PIRSF015894
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CIG8
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PhosphoSite |
PhosphoSite-Q8CIG8
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TrEMBL |
Q9CRT9
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UniProt Splice Variant |
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Entrez Gene |
27374
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UniGene |
Mm.196585
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RefSeq |
NP_038796
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MGI ID |
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MGI Symbol |
Prmt5
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OMIM |
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CCDS |
CCDS27091
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HPRD |
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IMGT |
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EMBL |
AF167573
AK014213
AK132414
AK165165
BC023905
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GenPept |
AAF04503
AAH23905
BAB29209
BAE21155
BAE38057
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