InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akt2

Summary

InnateDB Protein

IDBP-161458.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Akt2

Protein Name

thymoma viral proto-oncogene 2

Synonyms

2410016A19Rik; AW554154; PKB; PKBbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083081

InnateDB Gene

IDBG-161456 (Akt2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032287	peripheral nervous system myelin maintenance
GO:0032859	activation of Ral GTPase activity
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0072659	protein localization to plasma membrane
GO:2000147	positive regulation of cell motility
GO:2001275	positive regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:104874

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00169
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00233
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F8WHG5

UniProt Splice Variant

Entrez Gene

11652

UniGene

Mm.177194

RefSeq

MGI ID

MGI Symbol

Akt2

OMIM

CCDS

HPRD

IMGT

EMBL

AC074312

GenPept