Version 5.4
Mus musculus Protein: Mettl21a
Summary
InnateDB Protein IDBP-161505.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mettl21a
Protein Name methyltransferase like 21A
Synonyms 2310038H17Rik; AI464204; Fam119a;
Species Mus musculus
Ensembl Protein ENSMUSP00000050424
InnateDB Gene IDBG-161503 (Mettl21a)
Protein Structure
UniProt Annotation
Function Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys- 564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys- 561' in HSPA8 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0030544 Hsp70 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0006479 protein methylation
GO:0018022 peptidyl-lysine methylation
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1914349
InterPro IPR019410 Nicotinamide N-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF10294
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQL0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 67099
UniGene Mm.46394
RefSeq NP_080240
MGI ID
MGI Symbol Mettl21a
OMIM
CCDS CCDS15006
HPRD
IMGT
EMBL AK009673 AK009675 AK009678 AK009679 AK009680 AK009682 AK011433 AK033578 BC026952
GenPept AAH26952 BAB26430 BAB26431 BAB26434 BAB26435 BAB26436 BAB26437 BAB27618 BAC28371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca