InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Maff

Summary

InnateDB Protein

IDBP-161508.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maff

Protein Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094076

InnateDB Gene

IDBG-161506 (Maff)

Protein Structure

UniProt Annotation

Function

Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it self-dimerizes. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA- binding sites. May be involved in the cellular stress response.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}.

Disease Associations

Tissue Specificity

Highly expressed in the lung, lower expression in the brain, thymus, liver, spleen, intestine, kidney, heart, muscle, and ovary. Not significantly expressed in hematopoietic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation
GO:0045604	regulation of epidermal cell differentiation