InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vax2

Summary

InnateDB Protein

IDBP-161561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vax2

Protein Name

ventral anterior homeobox containing gene 2

Synonyms

Dres93;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035976

InnateDB Gene

IDBG-161559 (Vax2)

Protein Structure

UniProt Annotation

Function

Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. {ECO:0000269PubMed:10421837, ECO:0000269PubMed:10595508, ECO:0000269PubMed:11830578, ECO:0000269PubMed:21856776}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the developing and mature retina. {ECO:0000269PubMed:10421837, ECO:0000269PubMed:10595508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007409	axonogenesis
GO:0009950	dorsal/ventral axis specification
GO:0016055	Wnt signaling pathway
GO:0030900	forebrain development
GO:0043010	camera-type eye development
GO:0048048	embryonic eye morphogenesis
GO:0060041	retina development in camera-type eye