InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fzd5

Summary

InnateDB Protein

IDBP-161570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd5

Protein Name

frizzled homolog 5 (Drosophila)

Synonyms

5330434N09Rik; AI427138; Fz-5; Fz5; mFz5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067783

InnateDB Gene

IDBG-161568 (Fzd5)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11520064}; Multi-pass membrane protein {ECO:0000269PubMed:11520064}. Golgi apparatus membrane {ECO:0000269PubMed:11520064}; Multi-pass membrane protein {ECO:0000269PubMed:11520064}. Note=Localized at the plasma membrane and also found at the Golgi.

Disease Associations

Tissue Specificity

Expressed in eye, kidney, lung, chondrocytes, epithelial cells of the small intestine and gobelet cells of the colon. {ECO:0000269PubMed:8626800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0019901	protein kinase binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0000578	embryonic axis specification
GO:0001525	angiogenesis
GO:0001944	vasculature development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0008595	anterior/posterior axis specification, embryo
GO:0016055	Wnt signaling pathway
GO:0031076	embryonic camera-type eye development
GO:0031077	post-embryonic camera-type eye development
GO:0032729	positive regulation of interferon-gamma production
GO:0033077	T cell differentiation in thymus
GO:0043507	positive regulation of JUN kinase activity
GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0060061	Spemann organizer formation
GO:0060070	canonical Wnt signaling pathway
GO:0060561	apoptotic process involved in morphogenesis
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060716	labyrinthine layer blood vessel development
GO:0060718	chorionic trophoblast cell differentiation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071219	cellular response to molecule of bacterial origin
GO:1901382	regulation of chorionic trophoblast cell proliferation
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042995	cell projection
GO:0048471	perinuclear region of cytoplasm