InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mllt3

Summary

InnateDB Protein

IDBP-161583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mllt3

Protein Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

Synonyms

2210011H10Rik; 2610012I03Rik; 3830408D16Rik; Af9; D4Ertd321e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077232

InnateDB Gene

IDBG-161577 (Mllt3)

Protein Structure

UniProt Annotation

Function

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00376, ECO:0000269PubMed:11439343}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Strong expression in the spleen. {ECO:0000269PubMed:11439343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007379	segment specification
GO:0009952	anterior/posterior pattern specification
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway