Version 5.4
Mus musculus Protein: Ncan
Summary
InnateDB Protein IDBP-161653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncan
Protein Name neurocan
Synonyms C230035B04; Cspg3; Cspg3-rs; Tgfbit;
Species Mus musculus
Ensembl Protein ENSMUSP00000002412
InnateDB Gene IDBG-161651 (Ncan)
Protein Structure
UniProt Annotation
Function May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0051823 regulation of synapse structural plasticity
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:104694
InterPro IPR000436 Sushi/SCR/CCP
IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR002353 Type-2 ice-structuring protein
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold
PFAM PF00084
PF00193
PF00008
PF00059
PF07645
PF07686
PRINTS PR01265
PR00356
PIRSF
SMART SM00032
SM00445
SM00181
SM00034
SM00179
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P55066
PhosphoSite PhosphoSite-P55066
TrEMBL
UniProt Splice Variant
Entrez Gene 13004
UniGene Mm.471195
RefSeq NP_031815
MGI ID
MGI Symbol Ncan
OMIM
CCDS CCDS22358
HPRD
IMGT
EMBL AK082298 BC065118 X84727
GenPept AAH65118 BAC38458 CAA59216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca