InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxi1

Summary

InnateDB Protein

IDBP-161667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxi1

Protein Name

forkhead box I1

Synonyms

5830401E05Rik; Fkh10; FREAC6; HFH-3; Hfh3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058651

InnateDB Gene

IDBG-161665 (Foxi1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. {ECO:0000269PubMed:12642503, ECO:0000269PubMed:15173882}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in intercalated cells of the epithelium of the distal renal tubule. {ECO:0000269PubMed:15173882}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0009888	tissue development
GO:0042472	inner ear morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity