InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cadm1

Summary

InnateDB Protein

IDBP-161672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cadm1

Protein Name

cell adhesion molecule 1

Synonyms

2900073G06Rik; 3100001I08Rik; AI987920; Bl2; Igsf4; Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N; SgIGSF; ST17; SynCam; Tslc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083073

InnateDB Gene

IDBG-161668 (Cadm1)

Protein Structure

UniProt Annotation

Function

Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. {ECO:0000269PubMed:12202822, ECO:0000269PubMed:12606335, ECO:0000269PubMed:12799182, ECO:0000269PubMed:12826663, ECO:0000269PubMed:15158462, ECO:0000269PubMed:15707673, ECO:0000269PubMed:15811952, ECO:0000269PubMed:16605125, ECO:0000269PubMed:16612000, ECO:0000269PubMed:23209303}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12826663}; Single-pass type I membrane protein {ECO:0000269PubMed:12826663}. Cell junction, synapse. Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250UniProtKB:Q9BY67, ECO:0000255, ECO:0000269PubMed:12826663}.

Disease Associations

Tissue Specificity

Expressed in brain, lung, kidney, testis, heart, spleen and liver, but not expressed in skeletal muscle. In brain, enriched in the synaptic plasma membrane. Expressed dominantly in epithelial cells but not expressed in fibroblast cells (at protein level). {ECO:0000269PubMed:12202822, ECO:0000269PubMed:12242005, ECO:0000269PubMed:12606335, ECO:0000269PubMed:12826663}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0030165	PDZ domain binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001889	liver development
GO:0002376	immune system process
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007283	spermatogenesis
GO:0007416	synapse assembly
GO:0007420	brain development
GO:0008037	cell recognition
GO:0009826	unidimensional cell growth
GO:0016338	calcium-independent cell-cell adhesion
GO:0030154	cell differentiation
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050715	positive regulation of cytokine secretion
GO:0051606	detection of stimulus
GO:0060348	bone development

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1889272

InterPro

IPR003585 Neurexin/syndecan/glycophorin C
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00294
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R5M8