InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmb5

Summary

InnateDB Protein

IDBP-161693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmb5

Protein Name

proteasome (prosome, macropain) subunit, beta type 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022803

InnateDB Gene

IDBG-161691 (Psmb5)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib (By similarity). Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway. {ECO:0000250, ECO:0000269PubMed:19183883}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed in uterus at the embryo implantation site. {ECO:0000269PubMed:16434403}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006979	response to oxidative stress
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603	proteolysis involved in cellular protein catabolic process