InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmc4

Summary

InnateDB Protein

IDBP-161977.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmc4

Protein Name

proteasome (prosome, macropain) 26S subunit, ATPase, 4

Synonyms

CIP21; MIP224;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032824

InnateDB Gene

IDBG-161975 (Psmc4)

Protein Structure

UniProt Annotation

Function

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0001824	blastocyst development
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030163	protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016234	inclusion body
GO:0022624	proteasome accessory complex
GO:0031597	cytosolic proteasome complex

Protein Structure and Domains

PDB ID

MGI:1346093

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005937 26S proteasome subunit P45
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54775