InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mbp

Summary

InnateDB Protein

IDBP-161986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbp

Protein Name

myelin basic protein

Synonyms

C76307; golli-mbp; Hmbpr; mld; R75289; shi;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046185

InnateDB Gene

IDBG-161984 (Mbp)

Protein Structure

UniProt Annotation

Function

The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1- isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. {ECO:0000269PubMed:11145205}.

Subcellular Localization

Isoform 13: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 12: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 11: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 10: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 9: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 8: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 7: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 6: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 5: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 4: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.Isoform 3: Cytoplasm. Nucleus.Isoform 2: Cytoplasm. Nucleus.Isoform 1: Cytoplasm. Nucleus.

Disease Associations

Note=Defects in Mbp are a cause of dysmyelinating diseases such as the shiverer (SHI) and myelin deficient (MLD) diseases characterized by decreased myelination in the CNS, tremors, and convulsions of progressively increasing severity leading to early death. The shiverer mice only express isoform 2, the MLD mice have a reduced amount of Mbp.

Tissue Specificity

In the embryo, isoform 1-isoform 3 are found in neurons within the central nervous system (primarily in pioneer neurons important in the formation of the cortex) and the peripheral nervous system. They are also expressed in the thymus, gut, lung and kidney. In the adult, isoform 1-isoform 3 are highly expressed in the brain (mainly in brain regions rich in oligodendrocytes) and spleen. Lower levels are seen in the heart, kidney and lung. Isoform 2 is also found in cells of the immune system. The isoforms missing the 134 first amino acids (isoform 4- isoform 13) are almost exclusively produced in the myelin-forming cells, the mature oligodendrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0007568	aging
GO:0009636	response to toxic substance
GO:0021762	substantia nigra development
GO:0032570	response to progesterone
GO:0034612	response to tumor necrosis factor
GO:0042552	myelination
GO:0046689	response to mercury ion
GO:0050771	negative regulation of axonogenesis
GO:0061024	membrane organization
GO:0070542	response to fatty acid

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0033269	internode region of axon
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0043218	compact myelin
GO:0071944	cell periphery