Mus musculus Protein: Cdk20 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-162035.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Cdk20 | ||||||||||||||
Protein Name | cyclin-dependent kinase 20 | ||||||||||||||
Synonyms | 4932702G04Rik; AU019450; AW558027; Ccrk; CDCH; p42; PNQLARE; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000021939 | ||||||||||||||
InnateDB Gene | IDBG-162033 (Cdk20) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. {ECO:0000250, ECO:0000269PubMed:20159594}. | ||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:20159594}. Cytoplasm {ECO:0000269PubMed:20159594}. Cell projection, cilium {ECO:0000269PubMed:20159594}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:2145349 | ||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9JHU3 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9JHU3 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 105278 | ||||||||||||||
UniGene | Mm.404008 | ||||||||||||||
RefSeq | NP_444410 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Cdk20 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS26601 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AY005133 AY904369 BC031907 | ||||||||||||||
GenPept | AAF89089 AAH31907 AAW82351 | ||||||||||||||