Version 5.4
Mus musculus Protein: Awat1
Summary
InnateDB Protein IDBP-162150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Awat1
Protein Name acyl-CoA wax alcohol acyltransferase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000094088
InnateDB Gene IDBG-162148 (Awat1)
Protein Structure
UniProt Annotation
Function Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20) (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3588200
InterPro IPR007130 Diacylglycerol acyltransferase
PFAM PF03982
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2ADU9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 245533
UniGene Mm.77759
RefSeq NP_001074605
MGI ID
MGI Symbol Awat1
OMIM
CCDS CCDS41074
HPRD
IMGT
EMBL AL671299 BC147680 BC147683 BC147829 BC147832
GenPept AAI47681 AAI47684 AAI47830 AAI47833 CAM19589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca