Version 5.4
Mus musculus Protein: Nnmt
Summary
InnateDB Protein IDBP-162164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nnmt
Protein Name nicotinamide N-methyltransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034808
InnateDB Gene IDBG-162162 (Nnmt)
Protein Structure
UniProt Annotation
Function Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0010243 response to organonitrogen compound
GO:0031100 organ regeneration
GO:0032259 methylation
GO:0042493 response to drug
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1099443
InterPro IPR000940 Methyltransferase, NNMT/PNMT/TEMT
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01234
PRINTS
PIRSF PIRSF000384
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O55239
PhosphoSite PhosphoSite-O55239
TrEMBL Q9D9X3
UniProt Splice Variant
Entrez Gene 18113
UniGene Mm.458542
RefSeq NP_035054
MGI ID 2I62
MGI Symbol Nnmt
OMIM
CCDS CCDS23157
HPRD
IMGT
EMBL AF029756 AF044960 AK006371 BC028757 U86105 U86106 U86107 U86108
GenPept AAB94331 AAB94332 AAB94333 AAB94334 AAC77360 AAH28757 BAB24553

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca