InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cby1

Summary

InnateDB Protein

IDBP-162230.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cby1

Protein Name

chibby homolog 1 (Drosophila)

Synonyms

1110014P06Rik; arb1; CBY; Pgea1; PGEA14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023064

InnateDB Gene

IDBG-162228 (Cby1)

Protein Structure

UniProt Annotation

Function

Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (By similarity). Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000250, ECO:0000269PubMed:17261658, ECO:0000269PubMed:17403895}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in heart, brain, lung, liver, muscle, kidney and testis. Levels are approximately 3-fold higher in embryonic and adult heart than in lung or liver. {ECO:0000269PubMed:17261658}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0042802	identical protein binding

Biological Process

GO:0008104	protein localization
GO:0030178	negative regulation of Wnt signaling pathway
GO:0042384	cilium assembly
GO:0045444	fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055007	cardiac muscle cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway