InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr65

Summary

InnateDB Protein

IDBP-162233.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr65

Protein Name

G-protein coupled receptor 65

Synonyms

Dig1; Gpcr25; TDAG8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074581

InnateDB Gene

IDBG-162231 (Gpr65)

Protein Structure

UniProt Annotation

Function

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in thymus and at low levels in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010447	response to acidity
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031532	actin cytoskeleton reorganization
GO:0032862	activation of Rho GTPase activity
GO:0051496	positive regulation of stress fiber assembly

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:108031

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002282 Platelet-activating factor receptor
IPR005464 Psychosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01153
PR01649

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61038