Version 5.4
Mus musculus Protein: Ash1l
Summary
InnateDB Protein IDBP-162328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ash1l
Protein Name ash1 (absent, small, or homeotic)-like (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000088451
InnateDB Gene IDBG-162326 (Ash1l)
Protein Structure
UniProt Annotation
Function Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Chromosome {ECO:0000250}. Note=The relevance of tight junction localization is however unclear. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
GO:0034968 histone lysine methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0005923 tight junction
Protein Structure and Domains
PDB ID MGI:2183158
InterPro IPR001025 Bromo adjacent homology (BAH) domain
IPR001214 SET domain
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR003616 Post-SET domain
IPR006560 AWS
IPR011011 Zinc finger, FYVE/PHD-type
IPR017956 AT hook, DNA-binding motif
IPR019787 Zinc finger, PHD-finger
PFAM PF01426
PF00856
PF00439
PF02178
PF00628
PRINTS PR00503
PIRSF
SMART SM00439
SM00317
SM00297
SM00249
SM00508
SM00570
SM00384
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MY8
PhosphoSite PhosphoSite-Q99MY8
TrEMBL
UniProt Splice Variant
Entrez Gene 192195
UniGene Mm.413845
RefSeq NP_619620
MGI ID
MGI Symbol Ash1l
OMIM
CCDS CCDS17487
HPRD
IMGT
EMBL AC127377 AC140468 AF247132 AK033177 AK034679 AK088497 AK153783 BC052194
GenPept AAH52194 AAK26242 BAC28183 BAC28795 BAC40390 BAE32182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca