InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcl2l2

Summary

InnateDB Protein

IDBP-162349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl2l2

Protein Name

BCL2-like 2

Synonyms

AW048834; Bcl-w; bclw; c98; Gtrgal2; Gtrosa41;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022806

InnateDB Gene

IDBG-486097 (Bcl2l2)

Protein Structure

UniProt Annotation

Function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269PubMed:11784036, ECO:0000269PubMed:14746907, ECO:0000269PubMed:8761287}.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in almost all myeloid cell lines and in a wide range of tissues, with highest levels in brain, colon, and salivary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051400	BH domain binding

Biological Process

GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0060011	Sertoli cell proliferation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome