InnateDB Protein
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IDBP-162426.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ccdc99
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Protein Name
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coiled-coil domain containing 99
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Synonyms
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1700018I02Rik; 2600001J17Rik; 2810049B11Rik; AA409762; Ccdc99;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000090882
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InnateDB Gene
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IDBG-162424 (Ccdc99)
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Protein Structure
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Function |
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {ECO:0000255HAMAP-Rule:MF_03041}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP-Rule:MF_03041}. Chromosome, centromere, kinetochore {ECO:0000255HAMAP- Rule:MF_03041}. Nucleus. Cytoplasm, cytoskeleton, spindle pole {ECO:0000255HAMAP-Rule:MF_03041}. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. {ECO:0000255HAMAP-Rule:MF_03041}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917635
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q923A2
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PhosphoSite |
PhosphoSite-Q923A2
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TrEMBL |
Q9CT58
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UniProt Splice Variant |
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Entrez Gene |
70385
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UniGene |
Mm.194368
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RefSeq |
NP_081687
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MGI ID |
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MGI Symbol |
Spdl1
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OMIM |
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CCDS |
CCDS24541
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HPRD |
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IMGT |
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EMBL |
AK011138
AK012927
AK139553
BC006674
CR392356
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GenPept |
AAH06674
BAB27428
BAB28554
BAE24059
CAI51911
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