InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eid2

Summary

InnateDB Protein

IDBP-162500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eid2

Protein Name

EP300 interacting inhibitor of differentiation 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062345

InnateDB Gene

IDBG-162498 (Eid2)

Protein Structure

UniProt Annotation

Function

Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). {ECO:0000250UniProtKB:Q8N6I1}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q8N6I1}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, kidney and pancreas. Not detected in placenta. {ECO:0000269PubMed:14585496}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007181	transforming growth factor beta receptor complex assembly
GO:0007183	SMAD protein complex assembly
GO:0007517	muscle organ development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030154	cell differentiation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated